(i) Sudden appearance of fever with pain and sensation of cold shivering.
(ii) Body temperature rises up to 106°F and patient becomes burning hot. He or she experiences intense headache, faster breathing rate and heartbeat.
(iii) Fever later comes down with profuse sweating. This occurs either daily at a particular time or is repeated every third or fourth day depending upon the species of the parasite.
(iv) Enlargement of spleen and anacmia occurs